The film, a fresh take on Capcom's long-running horror franchise, opens in theaters on September 18, 2026, and is co-written by Cregger and Shay Hatten.
The cast includes Austin Abrams in the lead role of Bryan, with Zach Cherry, Kali Reis, Paul Walter Hauser, and Jonno Wilson among the credited performers.
The first spot centers on Bryan as he encounters an aggressive dog prodding its head through a hole in a fence.
Before the creature transforms, the moment is played for a beat of levity: Bryan half-jokingly questions why the animal is attacking him, then the dog erupts into a mutated form, its head splitting to reveal tentacle-like appendages that seize him.
The second commercial recycles footage from earlier trailers and serves primarily as a reminder of the film's broader nightmarish set pieces.
In-game history and creature design
Infected dogs are a recurring threat across the Resident Evil games.
Capcom's original Resident Evil introduced the Cerberus—dogs altered by Umbrella's bio-organic weapons research—while Resident Evil 2 and Resident Evil 3 featured Zombie Dogs as secondary victims of the Raccoon City t-Virus outbreak.
The canine in Cregger's film bears a closer resemblance to the Colmillos from Resident Evil 4, the Las Plagas–infested wolves known for sprouting tentacle-like growths.
Film context and creative team
Cregger, who garnered critical attention for his 2022 horror film Barbarian, is positioning this Resident Evil as a franchise reboot.
The movie follows medical courier Bryan as he attempts to deliver a crucial package through a nightmarish Raccoon City.
Universal Pictures is distributing the film, which aims to translate elements of Capcom's game-world threats to a live-action format.
Franchise reach and platform notes
Capcom's Resident Evil series has spanned multiple console generations and platforms, with entries and ports available on major systems including releases on Nintendo hardware.
The franchise's legacy—its monsters, Umbrella Corporation lore, and Raccoon City setting—remains a central reference point for adaptations like Cregger's film.
With its September 18, 2026 release date confirmed and multiple TV spots now circulating, audiences will soon see how the movie adapts familiar Resident Evil enemies for the big screen.
Journalists and fans can expect additional promotional material and images to appear as the release approaches.