The moment drew attention from retro gaming audiences because Last Bronx is not a frequently referenced title in mainstream TV trivia.
Last Bronx was developed by Sega AM3 and released to arcades in 1996, running on Sega's Model 2 arcade board.
Set in an alternate version of Tokyo, the game centers on a street-fighting tournament dubbed the All Tokyo Street Wars.
Sega later ported Last Bronx to the Sega Saturn in 1997, bringing the arcade experience to the home console during the Saturn's active life cycle.
On-air, O'Leary provided the correct answer during one of the show's final rounds.
Rewritten in journalistic terms: Dermot O'Leary identified the title Last Bronx when presented with a question about a Japanese city setting, a response that matched the show's correct answer.
Commentators noted that the question's reference to a Japanese urban setting made Tokyo an unsurprising contextual cue for contestants.
The Chase has featured several video game-related questions in recent seasons.
Earlier this year, former magazine editor Steve Jarratt, known for his tenure at EDGE, Official Nintendo Magazine and Total, also appeared on the show and faced gaming trivia.
Those appearances underline how video games, from arcade classics to modern releases, are increasingly finding their way into mainstream daytime television quizzes.
For context, Sega AM3 — the studio behind Last Bronx — was responsible for several arcade and console projects during the 1990s, often leveraging Sega's in-house hardware like the Model 2 board.
The Model 2 was notable for powering multiple arcade hits of the era, and Sega Saturn ports allowed home audiences to access arcade experiences despite hardware parity challenges between arcade boards and Saturn hardware.
While Last Bronx remains a niche entry compared with Sega franchises such as Virtua Fighter or Sonic the Hedgehog, its appearance on ITV's The Chase is a reminder of the enduring cultural footprint of 1990s arcade fighters.
Fans of retro Sega hardware and the Sega Saturn likely appreciated the spotlight on a title that helped define a particular era of arcade fighting game design.
Have you seen other surprising video game references on television quiz shows?
Readers with examples of odd or obscure gaming questions on TV are encouraged to share their experiences in the comments.